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Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma

Melanomas originating from mucosal surfaces have low mutation burden, genomic instability, and poor prognosis. To identify potential driver genes, we sequenced hundreds of cancer-related genes in 43 human mucosal melanomas, cataloguing point mutations, amplifications and deletions. The SPRED1 gene, which encodes a negative regulator of MAPK signaling, was inactivated in 37% of the tumors. Four distinct genotypes were associated with SPRED1 loss. Using a rapid, tissue-specific CRISPR technique to model these genotypes in zebrafish, we found that SPRED1 functions as a tumor suppressor, particularly in the context of KIT mutations. SPRED1 knockdown caused MAPK activation, increased cell proliferation and conferred resistance to drugs inhibiting KIT tyrosine kinase activity. These findings provide a rationale for MAPK inhibition in SPRED1-deficient melanomas and introduce a zebrafish modeling approach that can be used more generally to dissect genetic interactions in cancer.

Posted in AI & Robotics.


Robot backpack: How this Fusion bot aids collaboration

The Fusion bot shares and teaches skills by transferring body motions from one person to another.

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Posted in BBC Sci Tech.


Swift Navigation Case Study:<br>Yeti Snow Technology

Yeti has the goal to develop an autonomous snow clearing service for use on future airports. The product will be introduced in steps, in parallel with the development of technology for self-driving vehicles.

Posted in AI & Robotics.


It Will Be Possible to Integrate Exoskeletons Into Clothes

A stable wheelchair is automatically heavier. The same thing applies to exoskeletons. For a wearer to move about freely for an entire day, the battery has to be very powerful. But this means that it is also large and heavy.

Posted in AI & Robotics.


Robots & Humans Cooperating and Coexisting in the Future

I believe that systems will receive high-level strategic goals (“Build one car according to the following specification: …”) and will be autonomous in the way of how they achieve these goals, together with people

Posted in AI & Robotics.


Top Tech and Domestic Robot Holiday Gifts 2018

Here we are!


Holiday season is just around the corner and it's time to think about gifts for family and friends! Do not worry RobotShoppers, we are here to help you find the perfect gift for them! If you want help to find a domestic robot for your dear ones or a robotic kit for the adult robot nerd in the family, have a look below at our selection we prepared just for you.

           

Posted in AI & Robotics.


Top Robotic and Tech Toys Holiday Gifts 2018

With the holiday season just around the corner, many of us are looking for the perfect gift for our loved ones. It is sometimes difficult to find something to offer to a technology and/or robotics enthusiast.

Here is a list of the 2018 Top Robotic and Tech Toys for Holiday Gifts:

           

Posted in AI & Robotics.


Neurohype and the Law: A Cautionary Tale by Stephen Morse :: SSRN

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3245373

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Posted in IQ Corner.


10 Christmas Gift Ideas All About Robots

Christmas is getting close and its time to look for gift ideas. If you are looking for a gift for a robot fan, this post is for you. It lists robotic items for all budgets and all ages. $5-$15: Robot Movies for All Family $10-$12: Pluto Manga Comics Series $50: Robot Slippers with Sound $150: […]

… continue reading this post (10 Christmas Gift Ideas All About Robots) on Nootrix

Posted in AI & Robotics.


Bitcoin: The first ten years

Bitcoin was born ten years ago. What has it brought the world?

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Posted in BBC Sci Tech.